Pain is a major issue for people living with HIV and AIDS. People with HIV can experience pain in all parts of the body due to HIV infection and immunosuppression itself, HIV-related opportunistic infections and cancers, antiretroviral treatment, and related symptoms such as nutritional deficiencies. It affects all parts of the body and can significantly affect quality of life. Furthermore, people can experience two or three different types of pain at any one time. Despite the importance of tackling pain, it is very often left untreated. It is estimated that one million late-stage HIV patients suffer pain through lack of treatment in countries where there is insufficient or no access to pain relief for moderate or severe pain.